Sex- and phenotype-dependent metabolism of Nτ-methylhistidine by mice
نویسندگان
چکیده
منابع مشابه
Metabolism of N pi-methylhistidine in rats.
NƒÎ-Methylhistidine exists mostly, if not all, as one constituent of anserine in normal muscle (1). However, the free form of NƒÎ-methylhistidine came to appear in the muscle of rats fed on a methionine-excess diet (2). Urinary excretion of N methylhistidine was increased by a meat diet (3), a vitamin E-deficient (4), a histidine-excess (5) or a methionine-excess diet (2). On the other hand, or...
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Catechol-O-methyltransferase (COMT) has two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-MT), anchored to intracellular membranes. COMT is involved in the O-methylation of L-DOPA, dopamine and other catechols. The exact role of MB-COMT is still mostly unclear. We wanted to create a novel genetically modified mouse model that specifically lacks MB-COMT activ...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1986
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2390229